Current research in head and neck cancer: molecular by Henning Bier

By Henning Bier

The improvement of head and neck melanoma is a multistep technique during which genetic in addition to epigenetic changes intrude with the commonplace capabilities of proto-oncogenes and tumor suppressor genes. additionally, carcinogenesis is promoted by way of the impairment of mechanisms chargeable for the upkeep of genetic balance. the buildup of an important occasions resembling evasion of apoptosis, loss of senescence, deregulated proliferation, invasion and metastasis, in addition to neoangiogenesis ultimately determines the malignant phenotype. The sixteen articles of this quantity span from advances within the realizing of underlying molecular pathways (conditional mouse version, folate task, DNA fix, genomic heterogeneity, p53 relations, human papillomavirus), to preclinical and medical stories investigating capability novel healing pursuits.

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Without high-penetration genes one could expect that a risk results not only from an interaction of many polymorphisms, but also geneenvironment interaction [30] has to be taken into account. Acknowledgement This work was supported, in part, by the Polish State Committee for Scientific Research, grant No. 6 P05A 13620. References 1 2 3 4 Norppa H: Genetic susceptibility, biomarker responses and cancer. Mutat Res 2003;544:339–348. Mohrenweiser H, Jones IM: Variation in DNA repair is a factor in cancer susceptibility: A paradigm for the promises and perils of individual and population risk estimation.

25–75% Median 90 80 Comet length 70 60 50 40 30 20 10 K B[a]P Cases B[a]R/R K B[a]P B[a]R/R Controls Fig. 2. B[a]P-induced DNA damage and its removal from lymphocytes proliferating in vitro shown as an average comet length calculated for larynx cancer subjects and healthy controls. B[a]P was activated by S9 microsomal fraction. K ϭ control; R ϭ repair. Gajecka/Rydzanicz/Jaskuta-Sztul/Wierzbicka/Szyfter/Szyfter 28 70 ϪB[a]P ϩB[a]P Median comet length 60 50 40 30 20 10 0 G1 G2 G3 Fig. 3. Spontaneous and mutagen-induced DNA damage in human lymphocytes in vitro as a function of the histological classification of laryngeal tumour.

Bockmühl U, Schluns K, Schmidt S, Matthias S, Petersen I: Chromosomal alterations during metastasis formation of head and neck squamous cell carcinoma. Genes Chromosomes Cancer 2002;33:29–35. Fleming ID, Cooper JS, Henson DE, Hutter RVP, Kennedy BJ, Murphy GP, et al (eds): American Joint Committee on Cancer Staging Manual, ed 5. Philadelphia, Lippincott-Raven, 1997. Telenius H, Pelmear AH, Tunnacliffe A, Carter NP, Behmel A, Ferguson-Smith MA, Nordenskjold M, Pfragner R, Ponder BA: Cytogenetic analysis by chromosome painting using DOP-PCR amplified flow-sorted chromosomes.

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