Computer-Aided Drug Design and Delivery Systems by Ahindra Nag

By Ahindra Nag

The newest BREAKTHROUGHS IN COMPUTER-AIDED DRUG layout AND supply This definitive textual content offers in-depth info on computer-assisted concepts for locating, designing, and optimizing new, powerful, and secure medications. Computer-Aided Drug layout and supply platforms deals aim and quantitative information at the use and supply of gear in people. permitting applied sciences akin to bioinformatics, pharmacokinetics, biosensors, robotics, and bioinstruments are completely mentioned during this cutting edge paintings. insurance contains: Computer-aided drug layout (CADD) Drug supply platforms Bioinformatics of drug molecules and databases Lipase- and esterase-mediated medicines and drug intermediates Pharmacokinetics and pharmacodynamics of substances Biomarkers, biosensors, and robotics in medication Biomedical instrumentation

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1 percent of total DNA. These differences are mostly point mutations. These so-called single-nucleotide polymorphisms (SNPs) become good candidates for drug development. Investigations of SNPs using microarrays made examination of the entire population feasible. Databases of SNPs reveal the causes of cancer and so on. Cellomics. For carrying out investigations on complex interactions, the availability of sufficient data and identification of the relevant components of life are very essential. Simulations of life 41 42 Chapter Three in silico constitute a future direction for bioinformatics that has just begun.

Nature of the patient 5. Length of therapy 6. 1â•… Aqueous Solubility and pKa Aqueous solubility of a drug influences its dissolution rate and hence the absorptive power of the drug. Since most drugs are either weak acids or weak bases, pKa is also an important parameter in drug absorption. The pH of the gastric or intestinal fluid and the pH of the blood are indicative of the driving force for absorption based on pH gradient. 3â•… Drug Stability Generally, a drug in the solid state undergoes degradation at a much slower rate than a drug in solution or suspension.

5â•… Microreservoir Dissolution-Controlled Devices Transdermal devices can be evaluated for their drug release and permeation kinetics by using a two-compartment diffusion cell assembly. The different types of diffusion cells can be summarized on the basis of their physical design and methods of sampling and measurement. Among the various diffusion cells used, Franz diffusion cell is the most commercialized. 15â•… In Vitro Release Kinetics Controlled-release kinetics of drugs from technologically diffusion transdermal therapeutic systems can be evaluated and compared by using a Franz diffusion cell assembly.

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