By Peter Fratzl
Collagen: constitution and Mechanics presents a cohesive advent to this organic macromolecule and its many purposes in biomaterials and tissue engineering.
Graduate scholars and postdoctoral researchers within the fields of fabrics, (bio-)engineering, physics, chemistry and biology will achieve an realizing of the constitution and mechanical habit of sort I collagen and collagen-based tissues in vertebrates, throughout all size scales from the molecular (nano) to the organ (macro) point. Written in a transparent and didactic demeanour, this quantity comprises present wisdom at the hierarchical constitution, mechanical homes, as well as a assessment of deformation and strengthening mechanisms.
Collagen: constitution and Mechanics is a superb reference for brand spanking new researchers getting into this area and serves as a foundation for lecturing within the interdisciplinary box of organic fabrics science.
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Additional info for Collagen: Structure and Mechanics
2006). The results showed that inactivation of LH had relatively little effect (probably due to partial compensation by other forms of LH), but inactivation of the entire molecule, including the GGT activity, was embryonic lethal, apparently due to disruption of basement membranes. Thus, O-linked glycosylation of collagens is essential for normal development. 2 Chain Association and Triple-Helix Formation Following prolyl and lysyl hydroxylation and O-linked glycosylation in the rough endoplasmic reticulum, procollagen ␣ chains then associate to form the procollagen molecule.
Hulmes a result of the cyclic nature of the side chains that restricts flexibility about the peptide bond. Prolyl hydroxylation provides further stabilization, as shown by the approximately 30◦ C drop in melting temperature (see below) when this process is prevented. Hydroxylation occurs mainly on prolines in the Y position of the Gly-X-Y triplet, through the action of prolyl 4-hydroxylases (P4H), and also to a much lesser extent on prolines in the X-position, through the action of prolyl 3-hydroxylases (P3H) (Fig.
1994) Hierarchical Structures in Biology as a Guide for new Materials Technology. National Academy Press: Washington. Shewry PR, Tatham AS, Bailey AJ, Eds. (2003) Elastomeric Proteins, Structures, Biomechanical Properties, and Biological Roles. Cambridge University Press: Cambridge. Vincent JFV (1990) Structural Biomaterials, Princeton University Press: Princeton. Wainwright SA, Biggs WD, Currey JD, Gosline JM (1982) Mechanical Design in Organisms. Princeton University Press: Princeton. Waite JH, Vaccaro E, Sun C, Lucas J (2003) Chapter 10, pp.