Chronic Hepatitis B and C : Basic Science to Clinical by Chiaho Shih

By Chiaho Shih

The scope of the booklet is particularly large, masking quite a lot of components in HBV/HDV and HCV learn, together with either simple and medical technology. the chosen issues diversity from epidemiology, immunology, molecular virology and oncology, to medical remedy.

Chronic Hepatitis B and C includes 14 chapters, every one being a evaluation of a different subject on HBV or HCV. whereas evaluate articles on a distinct subject are available in periodical journals, they generally tend to be extra limited in presentation. for this reason, this ebook will supply extra in-depth assurance of what are provided as "unpublished effects" and "data no longer proven" in magazine articles. additionally, numerous authors during this ebook don't write evaluate articles usually. a few authors wrote reports on a particular subject frequently, yet they attempted a brand new subject during this ebook (e.g., Dr. YF Liaw on traditional course," Dr. Shih on "virion release," Dr. Michael Lai on "lymphotropism of HCV," and so forth ... ). total, the e-book will provide helpful info on the slicing age.

Readership: Researchers in virology, infectious ailments and melanoma medicine.

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Sample text

84. Chu CM, Liaw YF. (2006) Hepatitis B virus-related cirrhosis: natural history and treatment. Semin Liver Dis 26: 142–152. 85. Liaw YF, Lin DY, Chen TJ, Chu CM. (1989) Natural course after the development of cirrhosis in patients with chronic type B hepatitis: a prospective study. Liver 9: 235–241. 86. Liaw YF, Chen JJ, Chen TJ. (1990) Acute exacerbation in patients with liver cirrhosis: a clinicopathological study. Liver 10: 177–184. 87. Fattovich G, Bortolotti F, Donato F. (2008) Natural history of chronic hepatitis B: special emphasis on disease progression and prognostic factors.

Recent studies using HBsAg quantitation have shown that there is an overall correlation between serum HBsAg and HBV DNA levels, especially in HBeAg-positive patients, and the HBsAg levels decrease slowly and gradually, being the highest in the immune tolerant phase, followed by HBeAg-positive chronic hepatitis, HBeAg-negative chronic hepatitis, and the lowest in the inactive residual phase,96–98 as shown in Table 1. However, there are more to learn before HBsAg quantitation is applied in clinical use.

The serologic profile and absence of liver disease in asymptomatic carriers is consistent with an exclusive Th2-like response. Alternatively, the serology and evidence of immune-mediated cytotoxic responses in chronic active hepatitis patients suggest a Th1like or combined Th1/Th2-like response. In addition to the diagnostic value of more sensitive immunoassays, these results suggest possible therapeutic approaches for terminating the chronic carrier state. For example, it may be beneficial to convert a predominantly Th2-type HBeAg-specific Th cell response into a Th1-predominant response that may mediate viral clearance more efficiently.

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