Chemical Toxicity Prediction: Category Formation and by Mark Cronin, Judith Madden, Steven Enoch, David Roberts,

By Mark Cronin, Judith Madden, Steven Enoch, David Roberts, Diana Anderson

The objective of this e-book is to supply the clinical history to utilizing the formation of chemical different types, or teams, of molecules to permit for read-across i.e. the prediction of toxicity from chemical constitution. It covers the clinical foundation for this method of toxicity prediction together with the ways to staff compounds (structural analogues and / or similarity, mechanism of motion) and the instruments to accomplish this. The ways to accomplish read-across inside of a chemical classification also are defined. The ebook will offer concise sensible advice for these wishing to use those tools (in hazard / probability evaluation) and may be illustrated with case stories. Chemical Toxicity Prediction is the 1st e-book that addresses the idea that of classification formation and read-across for toxicity prediction particularly. This subject has relatively taken off some time past few years because of issues over facing the achieve laws and likewise as a result of the availability of the OECD (Q)SAR Toolbox. a lot (lengthy and intricate) suggestions is obtainable on classification formation e.g. from the OECD and, to a lesser volume, the ecu chemical substances organization yet there's no one unmarried resource of data that covers all concepts in a concise trouble-free layout. there's a genuine want for this knowledge as in silico toxicology has come to the fore in recent times, essentially a result of ecu achieve laws, but additionally because of many different drivers e.g. aid of animal checking out, Cosmetics rules. type formation is obvious because the in basic terms useful method of make rational and obvious predictions for complicated (human) toxicological endpoints. The ebook covers the entire components required to create a strong class and practice read-across.

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