Cell and matrix mechanics by Roland Kaunas, Assaf Zemel

By Roland Kaunas, Assaf Zemel

Explores various Multiscale Biomechanics/Mechanobiology Concepts

Cell and Matrix Mechanics presents state of the art examine on the molecular, mobile, and tissue degrees within the box of mobile mechanics. This ebook consists of key specialists within the box, and covers the most important parts of phone and tissue mechanics, with an emphasis at the roles of mechanical forces in cell–matrix interactions. offering fabric in each one bankruptcy that builds at the prior chapters, it successfully integrates size scales and comprises, for every size scale, key experimental observations and corresponding quantitative theoretical versions.

Summarizes the 3 Hierarchical degrees of cellphone Mechanics

The ebook comprises 14 chapters and is geared up into 3 sections. the 1st part specializes in the molecular point, the second one part info mechanics on the mobile point, and the 3rd part explores mobile mechanics on the tissue point. The authors provide a radical description of the jobs of mechanical forces in phone and tissue biology, and contain particular examples. They include descriptions of linked theoretical versions, and supply the information and modeling framework wanted for a multi-scale research. furthermore, they spotlight the pioneering reports in cell–matrix mechanics by way of Albert ok. Harris.

The issues coated include:

  • The passive and lively mechanical homes of cytoskeletal polymers and linked motor proteins besides the habit of polymer networks
  • The mechanical homes of the cellphone membrane, with an emphasis on membrane protein activation brought on by membrane forces
  • The hierarchical association of collagen fibrils, revealing soft stability exists among particular and nonspecific interactions to lead to a constitution with semicrystalline order in addition to free associations
  • The roles of matrix mechanical homes on telephone adhesion and serve as besides diversified mechanical mechanisms of cell–cell interactions
  • The results of mechanical loading on mobilephone cytoskeletal home improvement, summarizing numerous modeling ways that designate attainable mechanisms regulating the alignment of actin pressure fibers in line with stretching
  • The mechanical checking out of cell-populated collagen matrices, in addition to conception touching on the passive and lively mechanical houses of the engineered tissues
  • Cell migration habit in three-D matrices and in collective phone motility
  • The function of mechanics in cartilage development
  • The roles of either mobile and exterior forces on tissue morphogenesis
  • The roles of mechanical forces on tumor progress and melanoma metastasis

Cell and Matrix Mechanics succinctly and systematically explains the jobs of mechanical forces in cell–matrix biology. Practitioners and researchers in engineering and physics, in addition to graduate scholars in biomedical engineering and mechanical engineering relating to mechanobiology, can take advantage of this paintings.

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