Case Files: Biochemistry, 2nd Edition by Eugene C. Toy, William E. Seifert Jr., Henry W. Strobel,

By Eugene C. Toy, William E. Seifert Jr., Henry W. Strobel, Konrad P. Harms

Fifty scientific situations assist you excel in biochemistry classes and the USMLE Step 1

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The patient has mild cervical lymph node enlargement but otherwise has a normal examination. ◆ What is the most likely diagnosis? ◆ What is the biochemical mechanism of action of ribavirin? ◆ What is the genetic make up of this infectious organism? 18 CASE FILES: BIOCHEMISTRY ANSWERS TO CASE 2: RIBAVIRIN AND INFLUENZA Summary: A college student complains of the sudden onset of fever, chills, malaise, nonproductive cough, and numerous sick contacts in the fall season. ◆ ◆ Likely diagnosis: Acute influenza infection Biochemical mechanism of action of ribavirin: A nucleoside analogue with activity against a variety of viral infections ◆ Genetic makeup of organism: Ribonucleic acid (RNA) respiratory virus CLINICAL CORRELATION This 21-year-old college student has the clinical clues suggestive of acute influenza.

New York: Wiley-Liss, 2002. ❖ CASE 4 A 47-year-old female is brought to the emergency department with complaints of malaise, nausea and vomiting, and fatigue. ” She has been to rehab on several occasions for alcoholism but has not been able to stop drinking. She is currently homeless and jobless. She denies cough, fever, chills, upper respiratory symptoms, sick contacts, recent travel, hematemesis, or abdominal pain. She reports feeling hungry and has not eaten very well in a long time. On physical exam she appears malnourished but in no distress.

Weatherall DJ, et al. The hemoglobinopathies. , eds. The Metabolic & Molecular Basis of Inherited Disease, 8th ed. New York: McGraw-Hill, 2001. This page intentionally left blank ❖ CASE 2 A 21-year-old college student presents to the clinic complaining of a sudden onset of chills and fever, muscle aches, headache, fatigue, sore throat, and painful nonproductive cough 3 days prior to fall final exams. Numerous friends of the patient in the dormitory reported similar symptoms and were given the diagnosis of influenza.

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