Bioprocess Engineering. An Introductory Engineering and Life by K.G. Clarke (Auth.)

By K.G. Clarke (Auth.)

Biotechnology is an expansive box incorporating services in either the lifestyles technological know-how and engineering disciplines. In biotechnology, the scientist is worried with constructing the main beneficial biocatalysts, whereas the engineer is directed in the direction of procedure functionality, defining stipulations and methods that would maximize the construction capability of the biocatalyst. more and more, the synergistic influence of the contributions of engineering and lifestyles sciences is recognized as key to the interpretation of latest bioproducts from the laboratory bench to advertisement bioprocess. primary to the profitable recognition of the bioprocess is a necessity for strategy engineers and existence scientists efficient in comparing organic structures from a cross-disciplinary standpoint. Bioprocess engineering goals to generate center potential via an knowing of the complementary biotechnology disciplines and their interdependence, and an appreciation of the demanding situations linked to the appliance of engineering ideas in a existence technological know-how context. preliminary chapters concentrate on the microbiology, biochemistry and molecular biology that underpin biocatalyst strength for product accumulation. the subsequent chapters enhance kinetic and mass move rules that quantify optimal approach functionality and scale up. The textual content is extensive in scope, when it comes to bioprocesses utilizing bacterial, fungal and enzymic biocatalysts, batch, fed-batch and non-stop thoughts and loose and immobilised configurations.

  • Details the appliance of chemical engineering ideas for the advance, layout, operation and scale up of bioprocesses
  • Details the information in microbiology, biochemistry and molecular biology correct to bioprocess layout, operation and scale up
  • Discusses the importance of those existence sciences in defining optimal bioprocess performance

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Extra resources for Bioprocess Engineering. An Introductory Engineering and Life Science Approach

Sample text

The lac operon was evaluated by François Jacob (b. 1920) and Jacques Monod (1910–1976). This represented the first example of transcriptional regulation of the structural genes on an operon. 20. Combination of glucose and galactose. 21. First published by Jacques Monod in 1949 during batch culture of E. coli in a mixed carbon source of glucose and sorbitol. 22. Kary Banks Mullis (b. 1944), Nobel prize 1993. 23. Food and Drug Administration, USA. 53 Abstract: Efficient utilisation of the carbon source impacts significantly on the ability of the microorganism to maintain its cellular integretity, to grow and reproduce and, from the process perspective, to produce the desired product.

In a form which is unable to prevent transcription. 50 Published by Woodhead Publishing Limited, 2013 Molecular biology 18. Induction by a substrate molecule is referred to as substrate induction. Induction by a molecule not acted on by the enzyme is referred to as gratuitous induction. 19. The lac operon was evaluated by François Jacob (b. 1920) and Jacques Monod (1910–1976). This represented the first example of transcriptional regulation of the structural genes on an operon. 20. Combination of glucose and galactose.

Inorganic nitrogen sources include NH3, NH4+, NO3− and NO2−. Organic nitrogen sources such as yeast extract, peptone and whey not only contain nitrogen but also certain growth factors. A preference for an organic source may simply indicate a requirement for one or other amino acid or vitamin contained in the organic source. Amino acids and vitamins can be added separately to a nutrient medium containing inorganics only if required but this is expensive and so limited to small scale bioprocesses.

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