Biomaterials for Cancer Therapeutics. Diagnosis, Prevention by K. Park (Eds.)

By K. Park (Eds.)

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K. Han, Y. W. Choi, J. H. Lee, J. Y. Lee and S. H. Yuk (2004). Hydrogenbonded polymer gel and its application as a temperature-sensitive drug delivery system. Biomaterials 25(12), 2393–2398. , P. M. Fong, J. Lu, K. S. Russell, C. J. Booth, W. M. Saltzman and T. M. Fahmy (2009). PEGylated PLGA nanoparticles for the improved delivery of doxorubicin. Nanomedicine 5(4), 410–418. Park, J. , G. Saravanakumar, K. Kim and I. C. Kwon (2010). Targeted delivery of low molecular drugs using chitosan and its derivatives.

2009). Prior to entry into cell division, these polarized epithelial cells must down-regulate (disconnect) these cell‒cell © Woodhead Publishing Limited, 2013 Cancer cell biology 23 contacts to eliminate their suppressive function on mitosis (Fig. 1). ) can then support the growth and replication of these non-polarized cells until the required numbers are obtained and cell proximity leads to the formation of nascent cell‒cell contacts, and the suppressive role of these structures once again stops polarized cells from continuing to proliferate.

Let us consider how polarized epithelium of the colon undergo normal repair to replace cells that are lost due to normal growth, frank lesions, senescence, etc. In the polarized, differentiated state, these epithelial cells are linked together through cell‒cell contacts that include tight junction, adherens junction, and gap junction structures. , 2009). Prior to entry into cell division, these polarized epithelial cells must down-regulate (disconnect) these cell‒cell © Woodhead Publishing Limited, 2013 Cancer cell biology 23 contacts to eliminate their suppressive function on mitosis (Fig.

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