By John J. Langone (Eds.)
The severely acclaimed laboratory regular, Methods in Enzymology, is without doubt one of the such a lot hugely revered guides within the box of biochemistry. because 1955, every one quantity has been eagerly awaited, often consulted, and praised via researchers and reviewers alike. The sequence includes a lot fabric nonetheless correct at the present time - actually an important e-book for researchers in all fields of existence sciences
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Extra resources for Antibodies, Antigens, and Molecular Mimicry
Schreiber et al. attributed this discrepancy in the results to the impurity of the immunogen and the immunization schedule. 13° They investigated the transient nature of the antireceptor anti-idiotypic response, which was shown to be cyclical and corresponded to the production of antibodies that could bind to/3-AR and stimulate adenylate cyclase. Disappearance of the antireceptor antibodies in the serum coincided with appearance of adrenergic ligand-binding activity, corresponding to the development of the autologous anti-anti-idiotypic antibodies (Ab3) directed against the induced anti-idiotypic molecules.
This study emphasizes the existence of an idiotype-anti-idiotype network in parasitic infections. Such a network can be regulated so that beneficial protective immunity can be induced. Phillips et al. 72 studied a functional idiotype-anti-idiotype network that is germane to regulation in schistosomiasis. They studied interaction of antigen, idiotypes, and anti-idiotypes in the immune system and established correlations with resistance to parasitemia. What is interesting is that different monoclonal antibodies with the same epitopic specificity behave differently in terms of rendering protective immunity.
K6hler, lmmunol. Rev. 90, 29 (1986). 134T. Kieber-Emmons, E. Getzoff, and H. K6hler, Int. Reo. lmmunol. 2, 339 (1987). 135 p. M. Coleman, G. M. Air, R. G. Webster, J. N. Vargehese, A. T. Baker, M. R. Leutz, P. A. Tullock, and W. G. Laver, Immunol. Today 8, 323 (1987). ~36C. Bruck, M. S. Co, M. Slaoui, G. N. Gaulton, T. Smith, B. N. Fields, J. I. Mullins, and M. I. Greene, Proc. Natl. Acad. Sci. A. 83, 6578 (1986). m G. Mazza, P. Oilier, G. Somm6, D. Moinier, J. Rocca-Serra, J. Van Rietschoten, J.