Animal Models of Ophthalmic Diseases by Chi-Chao Chan

By Chi-Chao Chan

This booklet describes experimental animal types that mimic universal human ocular illnesses: herpetic keratitis, cataract, glaucoma, age-related macular degeneration, diabetic retinopathy, uveitis, retinitis pigmentosa, Graves’ ailment, and intraocular tumors. In conjunction, those versions replicate the variety and software of instruments used to review human illness. global specialist clinicians talk about every one version in line with their medical adventure and the textual content is supported by means of a number of images and diagrams. In describing the main pertinent animal types of ophthalmic ailments, this publication can be of curiosity to ophthalmologists, imaginative and prescient researchers, fellows, citizens and scientific students.

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005 Kronschlager M, Lofgren S, Yu Z, Talebizadeh N, Varma SD, Soderberg P (2013) Caffeine eye drops protect against UV-B cataract. Exp Eye Res 113:26–31. 015 Lassen N, Bateman JB, Estey T, Kuszak JR, Nees DW, Piatigorsky J, Duester G, Day BJ, Huang J, Hines LM, Vasiliou V (2007) Multiple and additive functions of ALDH3A1 and ALDH1A1: cataract phenotype and ocular oxidative damage in Aldh3a1(−/−)/ Aldh1a1(−/−) knock-out mice. J Biol Chem 282(35):25668–25676. M702076200 Lee AY, Chung SK, Chung SS (1995) Demonstration that polyol accumulation is responsible for diabetic cataract by the use of transgenic mice expressing the aldose reductase gene in the lens.

2008). Most recent work using the UVBinduced rat model has focused on determining potential anti-cataract/protective agents. For example, caffeine has been shown to have in vitro and in vivo protective effects against UVB irradiation in rats (Kronschlager et al. 2013; Varma et al. 2008). The lens contains a high concentration of reduced glutathione (GSH), which acts to eliminate oxidants and protect against exogenous and endogenous ROS. Caffeine is thought to protect against UVR-induced cataract by scavenging ROS (Giblin 2000; Lou 2003; Spector et al.

However, advances in intraocular lens (IOL) design and surgical technique over the past 20 years have resulted in a dramatic reduction in reported PCO rates, to occurrence in 14–18 % of patients (Schaumberg 2 Animal Models of Cataracts et al. 1998; Wormstone 2002; West-Mays and Sheardown 2010; Wormstone et al. 2009). Yet, PCO remains a major medical problem with profound consequences for the patient’s well-being and is a significant financial burden due to the costs of follow-up treatment. Multiple experimental animal models of PCO have been created, including in vivo, in vitro, and ex vivo approaches (West-Mays and Sheardown 2010; Wormstone et al.

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