By S Cortassa; et al
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Extra resources for An introduction to metabolic and cellular engineering
2000). The phenotypic consequences of gene inactivation depend on genetic background and pleiotropic effects (see Chapter 7). The latter implies on the one hand, that a gene knockout can result in different phenotypes when it performs in different genetic backgrounds (Miklos and Rubin, 1996), and on the other hand that specific environmental conditions may decide when the knockout of a certain gene may be lethal, or the effect of a mutation manifested. Most of the yeast genome encodes proteins that are synthesized during vegetative growth.
6). Organized complexity is generated by the cross-talk between these two opposing, but complementary, flows of information. g. entrainment. Relevant to the functional behavior of cells or tissues, are the mechanisms through which dynamic organization under homeodynamic conditions is achieved; MCE of these dynamic aspects has not yet begun (see Chapter 5). Coherence may arise from the synchronization in space and time of molecules, or the architecture of supramolecular or supracellular structures, through self-organization, in an apparent, "purposeful", functional way.
The relationship of genes to cell form and function is not like that of genes to proteins. , 1987; Harold, 1990; Aon and Cortassa, 1997). , 2001). e. the entire complement of messenger RNA (mRNA) molecules, proteins or metabolites in a tissue, organ or organism varies with physiological, pathological or developmental conditions (Oliver, 2000). Unlike mRNA molecules, proteins and metabolites are functional entities within the cell. For S. cerevisiae there are fewer than 600 low-molecular-weight intermediates, whereas there are ca.