Advances in Clinical Chemistry, Vol. 6 by Harry Sobotka (Ed.), C.P. Stewart (Ed.)

By Harry Sobotka (Ed.), C.P. Stewart (Ed.)

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Nevertheless, the concentration is not very h i g h 4 . 7% of mammalian bone ash. 39%, or 325 meq/kg (B12). On the other hand, MacIntyre et al. (M7) give figures ranging from 212 to 233 meq/kg dry fat-free bone from biopsy material and quote from Shohl (S4) a figure of 163 meq/kg from autopsy material. 34 C. P. STEWART AND S . C. FRAZER In experimental magnesium deficiency in rats (M6), the bone magnesium fell from the control level of about 300 meq/kg dry fat-free bone to about half that level in 3 weeks and thereafter continued to fall but only slowly.

28 meq/l). If one assumes that both cells and plasma in this series gave results too high by about the same amount and corrects accordingly, the figures for cells come into line with those of Kunkel (K6). 2. MAGNESIUM The predilection of magnesium for an intracellular location is shown also by the concentrations found in the various soft tissues. 3. In human muscle from the abdominal and chest walls, flame spectrophotometry gave a normal range of 63 to 78 meq Mg per kg of dry fat-free tissue (five cases; mean 71) (M7).

Experiments where isotopic magnesium has been given parenterally and radioactivity counts have been made on the stools suggest that failure to reabsorb the magnesium of intestinal secretions does not materially influence magnesium ,balance in normal subjects ( S5). Similar conclusions were reached following parenteral injections of magnesium gluconate ( M l ) . Considerable differences have been noted in the proportions of dietary magnesium supplements which are absorbed and appear in the urine.

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