Adenomatous Polyps of the Colon: Pathobiological and by Robert Lev

By Robert Lev

Adenomatous Polyps of the Colon: Pathobiological and Clinical Features consolidates the large physique of simple technology and scientific information linked to adenomatous polyps of the colon, a lot of it encouraged via the conclusion that almost all colorectal carcinomas appear to come up in such polyps. This e-book strives to guage those information, with specific emphasis on their implications for administration of polyp-bearing topics. themes comprehensively explored comprise anatomy and histology of the conventional colon; pathologic features of adenomatous polyps, differential prognosis, and grading schemes for measure of dysplasia and villosity; adenomatous polyposes; histologic and epidemiologic facts for the malignant strength of adenomatous polyps; and detection and administration, with exact realization to endoscopy, endoscopic polypectomy, the malignant polyp, and post-polypectomy surveillance schedules.

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It did demonstrate gaps in the lamina densa of the epithelial basement membrane in villous adenomas, through which epithelial cytoplasm extended into the lamina propria, and other findings indicative of decreased cell cohesiveness. , 1973) showed defective maturation of the adenomatous epithelium. The adenomatous cells of the upper crypts consisted mainly of incompletely differentiated absorptive and goblet cells, both of which are usually confined to the lower third of normal crypts. The absorptive cells, for example, had fewer and shorter microvilli than expected at the same crypt level, and absorptive and goblet cells had less rough endoplasmic reticulum.

Serial section studies of minute polyps in familial polyposis. Cancer 16:751-764. Lev R, Grover R (1981) Precursors of human colon carcinoma: A serial section study of colectomy specimens. Cancer 47:2007-2015. Lev R, Lebenthal E, Rossi T, Lance P (1987) Histochemical and morphological analysis of colonic epithelium from children with Gardner's syndrome and adults bearing adenomatous polyps. J Pediatr Gastroenterol Nutr 6:414-425. Lipkin M (1974) Phase I and phase II proliferative lesions of colonic epithelial cells in diseases leading to colonic cancer.

When tissue culture preparations are stimulated with the tumor promoter TPA (a phorbol ester), APs with significant dysplasia or villosity, and carcinomas, secrete the protease plasminogen activator (plasmin), whereas well-differentiated tubular adenomas and normal mucosa do not (Friedman, 1985). She speculated that that enzyme might help the carcinoma invade and destroy adjacent adenomatous tissue and thus account for the frequent inability to find adenomatous remnants in carcinomas. , 1987). In another study, normal colonic cells never survived when transplanted into nude mice, whereas adenoma cells survived for 28 days and colon carcinoma cells for 43 days (Bhargava & Lipkin, 1981).

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