By American Academy of Ophthalmology, Robert H. Rosa Jr. MD
Part four offers fabrics in components: half I, Ophthalmic Pathology; and half II, Intraocular Tumors: medical features. half I makes use of a hierarchy that strikes from normal to precise to aid derive a differential prognosis for a selected tissue. half II is a compilation of chosen medical facets of significance to the final ophthalmologist. Following half II are the yank Joint Committee on melanoma 2010 staging types for ocular and adnexal tumors.
Upon crowning glory of part four, readers could be capable to:
Describe a established method of knowing significant ocular stipulations in accordance with a hierarchical framework of topography, disorder procedure, common prognosis and differential diagnosis
Summarize the stairs in dealing with ocular specimens for pathologic learn, together with acquiring, dissecting, processing, and marking tissues
Identify these ophthalmic lesions that point out systemic disorder and are in all likelihood lifestyles threatening
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Additional info for 2014-2015 Basic and Clinical Science Course (BCSC): Section 4: Ophthalmic Pathology and Intraocular Tumors
Intraocular fibrocellular proliferation may occur after a penetrating injury. Such proliferation may lead to vitreous/ su bretinal/ choroid al hemorrhage; traction retinal detachment; proliferative vitreoretinopathy (PVR), including anterior PVR (Fig 2-9); hypotony; and ultimately phthisis bulbi. Formation of proliferative intraocular membranes may affect the timing of vitreoretinal surgery. The timing of the drainage of a ciliochoroidal hemorrhage is based on lysis of the blood clot (10- 14 days).
The epithelium is nonkeratinizing stratified squamous, with goblet cells. The conjunctiva! epithelium is continuous with the corneal epithelium, but the latter has no goblet cells. In the forniceal and bulbar areas, the conjunctiva! epithelium is flat and regular, while in the palpebral area, it exhibits ridges (Fig 5-lA, B). The goblet cells of the epithelium are most numerous in the fornices and plica semilunaris (Fig 5-lC, D). Beneath the epithelium is the conjunctiva! stroma, or substantia propria, which is thickest in the fornices and thinnest covering the tarsus.
Labeling of tissue (ink, sutures) to orient according to the diagram (for margins) Fine-Needle Aspiration Biopsy and Cytology 1. Previous communication with ophthalmic pathologist to discuss a. Logistics of the biopsy i. Possible adequacy check during the biopsy (intraocular tumors) ii . Fixative to be used iii. Fresh tissue for possible molecular diagnosis b. Specific cytology form to be filled out Flow Cytometry 1. Previous communication with ophthalmic pathologist to discuss a. Fresh tissue is critical.