2011-2012 Basic and Clinical Science Course, Section 9: by Ramana S. Moorthy MD

By Ramana S. Moorthy MD

Starts with an in-depth evaluation of immunemedicated eye disorder, summarizing simple immunologic techniques, ocular immune responses and certain subject matters in ocular immunology. Discusses the medical method of uveitis and experiences noninfectious (autoimmune) and infectious kinds of uveitis, with an improved part on viral uveitis and new fabric on infectious and noninfectious scleritis. more suitable detection of infectious brokers through immunologic and genetic equipment and new biologic therapeutics are distinctive. additionally covers endophthalmitis, masquerade syndromes, problems of uveitis and ocular facets of AIDS. incorporates a variety of new colour photos. significant revision 2011-2012

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Additional resources for 2011-2012 Basic and Clinical Science Course, Section 9: Intraocular Inflammation and Uveitis (Basic & Clinical Science Course)

Sample text

Into the efferent lymph fluid draining into the venous circulation. Antibodies the n mediate a variety of immune effector activities by combining with antigen in the blood or in tissues. Immune Response Arc and Primary or Secondary Immune Response Concept of Immunologic Memory Immunologic memory is probably the most distinctive feature of adaptive immune responses; protective immunization is the prototypical example of this powerful phenomenon. Classically. immunologic "memory" was the concept used to explain why serum antibody production for a specific antigen began much more quickly and rose to much higher levels afte r reexpos ure to that antigen but not after exposure to a different antigen.

Caspi R. Autoimmunity in the immune privileged eye: pathogenic and regulatory T cells. Im munol Res. 2008;42(1 - 3);41 - 50. von Andrien UH, Mackay CR. T-cell function and migration. Two sides of the same coin. N Engl J Med. 2000;343(14);1020- 1034. B-Iymphocyte activation One of the major regulatory functions for helper T lymphocytes is B-Iymphocyte activation. B lymphocytes are responsible for producing antibodies, which are glycoproteins that bind to a specific antigen. B lymphocytes begin as naive lymphocytes with immunoglobulin M (IgM) and IgD on the cell surface; these serve as the B-Iymphocyte antigen receptor.

Or helper. T lymphocytes (Fig 2-3). All APCs for CD4 T lymphocytes must express the MHC class II molecule. and the antigen receptor on the helper T lymphocyte can recognize peptide antigens only if they are presented with class II molecules Simultaneously. However. only certain cell types express MHC class II molecules on their plasma membrane. Macrophages and dendritic cells are the most important class II APCs. 8 lymphocytes can also function as class II-dependent APCs. especially within a lymph node.

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