2011-2012 Basic and Clinical Science Course, Section 11: by James C. Bobrow MD

By James C. Bobrow MD

Stories the anatomy, body structure, embryology and pathology of the lens. Covers the epidemiology, review and administration of cataracts; offers an outline of lens and cataract surgical procedure; and explores the issues and detailed occasions of cataract surgical procedure. final significant revision 2008 2009.

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Additional resources for 2011-2012 Basic and Clinical Science Course, Section 11: Lens and Cataract (Basic & Clinical Science Course)

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Genetic etiology of nuclear cataract: evidence fo r a major gene. Am I Med Gellet. 1993;47(8),1208- 1214. Iyengar SK, Klein BE, Klei n R, et al. Identificati on of a major locus fo r age-related cortical cataract on chromosome 6p12-q12 in the Beaver Dam Eye Study. Proc Na tl Acnd Sci USA . 2004; 101(40) ,14485- 14490. 52 • Len s and Cataract Drug-Induced Lens Changes Corticosteroids Long-term use of corticosteroids maycause PSCs. The incidence of corticosteroid-induced PSCs is related to dose and duration of treatment.

2004;10 :956- 963. Winkler J, WirbeJauer C, Frank V, Laqua H. Quantitative distributi on of glycosaminoglycans in young and senile (cataractous) anterior lens capsules. Exp Eye Res. 2001 ;72(3):311-3 18. This chapter was prepared with the assista nce of David Beebe, PhD. CHAPTER 4 Embryology Norma l Development The formation of the human crystalline lens begins very early in embryogenesis (Fig 4-1). At approximately 25 days of gestation. 2 lateral evaginations. called the optic vesicles. form from the forebrain .

39 Figure 4-14 Membranous ca taract. Membranous Membranous cataracts occur when lens proteins are resorbed from either an intact or a traumatized lens, allowing the anterior and posterior lens capsules to fuse into a dense white membrane (Fig 4-14). The resulting opacity and lens distortion generally cause significant visual disability. Rubella Maternal infection with the rubella virus, an RNA togavirus, can cause fetal damage, especially if the infection occurs during the first trimester of pregnancy.

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