2008-2009 Basic and Clinical Science Course: Section 9: by Ramana S. Moorthy, MD

By Ramana S. Moorthy, MD

A dialogue of the scientific method of uveitis results in widely rewritten chapters on noninfectious (autoimmune) and infectious varieties of uveitis. additionally lined are endophthalmitis, masquerade syndromes, and issues of uveitis. A dialogue on ocular involvement in AIDS has been up-to-date. The part on immunology describes the human immune reaction in phrases that make it hugely obtainable to readers.

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Extra info for 2008-2009 Basic and Clinical Science Course: Section 9: Intraocular Inflammation and Uveitis (Basic and Clinical Science Course 2008-2009)

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Intact soluble antigens gain entrance to the venous circulation, where they communicate with the spleen. The iris and ciliary body contain a rich investment of macrophages and dendritic cells that serve as APCs and possible effector cells. Immune processing is unlikely to occur locally, but APCs leave the eye by the trabecular meshwork and home to the spleen, where processing occurs that favors a Th2 response and preferential activation of CDS regulatory T lymphocytes. Few resident T lymphocytes and some mast cells are present in the normal anterior uvea; B lymphocytes, eosinophils, and neutrophils are not present.

EXAMPLES3-4 Retinal transplantation Transplantation of retina or RPE is being investigated as a method for regenerating retinal function in various disorders. In experimental animals, subretinal transplantation of fetal retinal tissue or various kinds of RPE allografts often show longer survival than the same grafts implanted elsewhere, even without systemic immunomodulation. The afferent phase recognition of alloantigens is likely performed by retinal microglia or recruited blood-derived macrophages from the choriocapillaris.

Intraocular Inflammation and Uveitis Immunologic Microenvironments Regional immunologic differences occur because different tissue sites are composed of different immunologic microenvironments. The concept of immunologic microenvironment incorporates a broad range of anatomical and physiologic differences among tissues or organs that regulate the immune response: . the presence of well-formed lymphatics · ·. · . specialized immunologic structures (Peyer patches or conjunctival follicles) blood-tissue barriers to macromolecules or cell migration type of resident APC constitutive synthesis of immunoregulatory cytokines or molecules by the parenchymal cell types many other factors The analysis of immunologic microenvironments has become important for understanding the immunology of transplantation, infection, and autoimmunity for gene therapy or many organ systems.

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